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Graphical presentation of CX-5461-mediated activation on the cytosolic DNA sensing pathway. cGAS binding to your cytosolic DNA activates the secondary messenger two,three-cGAMP applying cGAS as being a catalyst. Activated STING buds off the ER moving for the perinuclear Golgi, the place it truly is palmitoylated.Publisher’s Take note: MDPI stays
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